Byproducts of foods, supplements, and unintended chemicals can be easily tested using a simple urine sample.
Organic acids part of this test can help optimize your diet and supplements (e.g., vitamins, minerals, neurotransmitters, antioxidants or bacterial / fungal dysbiosis).
The environmental pollutants part can help understand exposure to harmful chemicals (from diet, supplements, or other unintended sources).
New! This most comprehensive test now covers almost 200 different markers for a thorough assessment of your symptoms.
Many natural and synthetic chemicals can be toxic, e.g., plastics in household products, food packaging, drugs, pesticides, dyes, or cleaning supplies. Using a urine tube, the test measures some of the most common chemicals (including BPA, parabens, PFAs, pesticides, herbicides, phenols, phthalates, benzene, toluene, styrene, lactate, citrate, & more).
Significant exposure to such chemicals is known to cause hormone imbalance, birth defects, and host of other problems.
The test is performed using Liquid Chromatography-Mass Spectrometry (LC-MS/MS/MS), Automated Chemistry & Immunochemistry for detecting extremely low levels with very high accuracy.
Our At-Home Organic Acids Panel + Environmental Pollutants Test is easy, fast, reliable, and requires just a few steps:
Order Online.
Receive The Test Kit And Collect Sample At Home.
Ship It Back For FREE* To Our World-Class CLIA Labs (US only).
Receive Secure, Confidential, & Easy-To-Understand Report Within Days** For Your Comprehensive Home Organic Acids + Environmental Pollutants Test.
* Includes FREE shipping of the kit to Canada & most other countries. Free Return shipping to the lab is available only within US.
** Please allow sufficient time to receive the kit, return the sample and testing by the lab. Due to large number of markers, this test may take 10-12 business days to complete testing.
Organic acids are carbon molecules released into the urine after digestion of foods and liquids. Each one of them follows a specific well-known biochemical pathway.
By checking their levels and correlating back via these pathways, it is possible to understand what was consumed and how the body is processing them.
Environmental pollutants are similar byproducts, but of products from industrial and manufacturing processes (e.g., pesticides) that are inhaled, consumed, or absorbed through skin.
These are often digested by the liver, and accumulate over time if exposed over longer periods.
Many of these pollutants are known carcinogens, may affect functioning of hormones, and even interfere with fertility and women's health.
Thus, a test of organic acids and environmental pollutants provides an excellent opportunity to understand our body's energy production, immune regulation, detoxification, neurotransmitter balance, and nutritional status.
This test is a combination of our Environmental Pollutants and Human Urine Metabolites (Organic Acids) Tests.
The organic acids part includes approximately 150 markers & environmental pollutants part includes about 50 markers (some might overlap though). These are divided into 12 different segments for better understanding of your results.
1. Microbial Overgrowth - for bacterial dysbiosis and overgrowth of potentially pathogenic organisms in the gastrointestinal tract, including phenolic and aromatic compounds produced by microbial fermentation of dietary substrates.
Key Markers
Benzoic Acid
Hippuric Acid
4-Hydroxybenzoic Acid (4-HBA)
3,4-Dihydroxybenzoic Acid (3,4-DHBA)
3-Hydroxyphenylacetic Acid (3-HPAA)
3,4-Dihydroxyphenylpropionic Acid (DHPPA)
Furancarbonylglycine
Amino Acid Metabolism
Phenylacetic Acid (PAA)
Phenylpropionic Acid
3-Phenyllactic Acid (3-PLA)
2-Hydroxyphenylacetic Acid (2-HPAA)
4-Hydroxyphenyllactic Acid (4-HPLA)
SCFA Metabolism
3-Hydroxypropionic Acid (3-HPA)
Clostridial Markers
4-Cresol
4-Hydroxyphenylacetic Acid (4-HPAA)
Indoleacetic Acid (IAA)
3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid (HPHPA)
2. Yeast & Fungal Metabolites - for yeast and fungal overgrowth, including Candida-related markers such as arabinitol, tartaric acid, and tricarballylic acid, which may interfere with mitochondrial function and nutrient absorption.
Key Markers
Arabinitol
Arabinose
Citramalic Acid
3-Oxoglutaric Acid
Aspergillus Markers
5-Hydroxymethyl-2-furoic Acid
Furan-2,5-dicarboxylic Acid
Tartaric Acid
Fusarium
Tricarballylic Acid
3. Mitochondrial & Energy Metabolism - for functional integrity of the citric acid (TCA) cycle through measurement of key intermediates including citric acid, cis-aconitic acid, isocitric acid, and alpha-ketoglutaric acid (supplements include B Comp, Cr, CoQ10, Lipoic Acid, Amino Acids, Mg).
Carbohydrate & Glycaemic Metabolism
Glucose (OA)
Pyruvic Acid
Lactic Acid
2-Hydroxybutyric Acid
Citric Acid Cycle
Citric Acid
cis-Aconitic Acid
Isocitric Acid
2-Oxoglutaric Acid
Succinic Acid
Fumaric Acid
Malic Acid
Ketone/Energy Intermediates
Acetoacetic Acid
3-Hydroxybutyric Acid
2-Hydroxybutyric Acid
Mitochondrial Markers
Methylsuccinic Acid
2-Methylglutaric Acid
3-Methylglutaric Acid
2-Hydroxyglutaric Acid
3-Hydroxyglutaric Acid
Malonic Acid
Mevalonolactone
2,4-Dihydroxybutanoic Acid
N-Acetylaspartic Acid
3-Methylglutaconic Acid
4. Fatty Acid Oxidation & Ketone Metabolism - for assessing the efficiency of both mitochondrial beta-oxidation and the alternative omega-oxidation pathway through dicarboxylic acid markers, providing insight into fatty acid handling, carnitine sufficiency, and metabolic flexibility.
Key Markers
Adipic Acid
Pimelic Acid
Suberic Acid
Azelaic Acid
Sebacic Acid
Ethylmalonic Acid
Propionylglycine
N-Butyrylglycine
Isovalerylglycine
N-(2-Methylbutyryl)glycine
3-Methylcrotonylglycine
Tiglylglycine
Hexanoylglycine
Suberylglycine
5. Vitamins & Nutritional Cofactor Markers - for functional assessment of B-vitamin status (B1, B2, B3, B5, B6, B12, folate, biotin), glutathione and antioxidant capacity, and key cofactors required for enzymatic activity across multiple metabolic pathways.
B-Vitamin Functional Markers
Methylmalonic Acid (MMA)
Formiminoglutamic Acid (FIGLU)
Xanthurenic Acid
Kynurenic Acid
Quinolinic Acid
Picolinic Acid
3-Hydroxyisovaleric Acid
Vitamin-specific/Antioxidant Markers
Pyroglutamic Acid
N-Acetylcysteine (NAC)
Glutaric Acid (Vit B2)
Pantothenic Acid (Vit B5)
Pyridoxic Acid (Vit B6)
Ascorbic Acid (Vit C)
Methylcitric Acid (Biotin/Vitamin H)
3-Hydroxy-3-methylglutaric Acid (CoQ10)
Pyrimidine Metabolites - Folate Metabolism
Thymine
Uracil
6. Amino Acid & Branched-Chain Metabolism - for the catabolism of essential and branched-chain amino acids, identifying impairments in leucine, isoleucine, valine, methionine, threonine, and tyrosine pathways that may contribute to fatigue, mood dysregulation, and neurological symptoms. For supplements that include B1, B2, B3, B5, B6, B12, Folate, Biotin.
Branched-Chain Ketoacids
2-Oxoisovaleric Acid
2-Oxoisocaproic Acid
3-Methyl-2-oxovaleric Acid
3-Methylglutaric Acid
Succinylacetone
Downstream Metabolites
2-Hydroxyisovaleric Acid
2-Hydroxyisocaproic Acid
2-Oxobutyric Acid
2-Oxo-4-methiolbutyric Acid (KMBA)
Amino Acid Metabolism
Phenylpyruvic Acid
Homogentisic Acid
N-Acetylphenylalanine
Mandelic Acid
Malonic Acid
4-Hydroxyphenyllactic Acid (4-HPLA)
2-Oxoadipic Acid
Guanidinoacetic Acid
Guanidinobutyric Acid
3-Methylglutaric Acid
N-Acetylglycine
7. Neurotransmitter Metabolism - for profiles of the major catecholamine and indole pathways, including dopamine, norepinephrine, and serotonin metabolites, as well as the tryptophan-kynurenine pathway, offering functional insight into mood, cognition, stress response, and sleep regulation. (For Phenylalanine, Tyrosine.)
Inhibitory (Serotonin)
5-Hydroxyindoleacetic Acid (5-HIAA)
Excitatory (Dopamine)
3,4-Dihydroxyphenylacetic Acid (DOPAC)
3-Methyl-4-hydroxyphenylglycol (MHPG)
Homovanillic Acid (HVA)
Vanillylmandelic Acid (VMA)
HVA/DOPAC Ratio
HVA/VMA Ratio
8. Detoxification & Glutathione Function - for evaluation of markers of phase I and phase II hepatic detoxification, glutathione cycling via pyroglutamic acid, and NAC status, reflecting the body's capacity to manage oxidative burden and chemical exposure. For Arg, NAC, Meth, Mg, Antioxidants.
Ammonia Metabolism
Orotic Acid
Glutathione Metabolism
Pyroglutamic Acid
N-Acetylcysteine (NAC)
Glucaric Acid
Phase I / Xenobiotic Markers
2-Hydroxyhippuric Acid
5-Hydroxymethyl-2-furoic Acid
Furan-2,5-dicarboxylic Acid
9. Oxidative Stress & Inflammation - for markers of DNA oxidative damage and inflammatory mediators, including 8-hydroxydeoxyguanosine and leukotriene E4, providing a functional picture of systemic oxidative load. For Vitamin C, Other Antioxidants.
Key Markers
8-hydroxy-deoxyguanosine
Leukotriene E4
Quinolinic Acid
Pyroglutamic Acid
Ascorbic Acid (Vitamin C)
Quercetin
10. Oxalate Metabolism - for markers of excess oxalate production or absorption, which may be associated with gut dysbiosis, dietary factors, or impaired detoxification.
Key Markers
Glycolic Acid
Glyceric Acid
Oxalic Acid
11. Environmental & Xenobiotic Exposures - for urinary metabolites of common environmental chemicals including xylene, benzene, toluene, phthalates, parabens, and endocrine-disrupting compounds such as Bisphenol A (BPA) and Bisphenol S (BPS), providing objective evidence of toxic load.
Toluene Exposure
Hippuric Acid
Benzoic Acid
Paraben Exposure
4-Hydroxybenzoic Acid (4-HBA)
Styrene Exposure
Mandelic Acid
Phenylglyoxylic Acid
Mandelic Acid + Phenylglyoxylic Acid
Benzene Exposure
t,t-Muconic Acid
Phthalate Exposure
Phthalic Acid
Monoethyl Phthalate
Quinolinic Acid
METB Exposure
2-HydroxyIsobutyric Acid
Xylene Exposure
2-Methylhippuric Acid
3-Methylhippuric Acid
4-Methylhippuric Acid
Trimethylbenzene Exposure
3,4-Dimethylhippuric Acid
4-Hydroxyhippuric Acid
Nucleotide Turnover/Methylation
5-Methylcytosine
Uracil
Thymine
12. Others.
Adrenal Stress (Overnight)
Cortisol (OA)
Tryptophan / Kynurenine Pathway (Tryptophan, B6, Antioxidants)
Inhibitory
5-Hydroxyindoleacetic Acid (5-HIAA)
Inflammatory
Kynurenic Acid
Quinolinic Acid
Picolinic Acid
Xanthurenic Acid
Kynurenic/Quinolinic Ratio
Quinolinic Acid/5-HIAA Ratio
Creatinine, Urine
Another list of 49 markers are tested for the environmental pollutants and are listed below under various categories.
Cysteine Derivatives
N-Acetyl (3,4-Dihydroxybutyl) cysteine (NADB)
N-Acetyl (carbomoylethyl) cysteine
N-Acetyl phenyl cysteine (SPMA)
N-Acetyl (propyl) cysteine (NAPR)
Environmental Phenols
4-Nonylphenol
Bisphenol A (BPA)
Triclosan (TCS)
Herbicides (Synthetic Auxins)
2,4-Dichlorophenoxyacetic acid (2,4-D)
Herbicides (Photosynthetic Inhibitors)
Atrazine
Atrazine mercapturate
Herbicides (EPSP Inhibitors)
Aminomethylphosphonic Acid (AMPA)
Glyphosate
Methyltert-Butyl Ether (MTBE) Exposure
2-HydroxyIsobutyric Acid
Mitochondrial Markers
Tiglylglycine
Parabens
Benzylparaben
Butylparaben
Ethylparaben
Methylparaben
4-Hydroxybenzoic Acid (4-HBA)
Propylparaben
Pesticides
3-Phenoxybenzoic Acid (3PBA)
Diethyl Phosphate (DEP)
Diethyldithiophosphate (DEDTP)
Diphenyl phosphate (DPP)
Diethylthiophosphate (DETP)
PFAs
Perfluorobutanoic acid (PFBA)
Perfluorooctanoic Acid (PFOA)
Perfluorooctane Sulphonic Acid (PFOS)
Phthalates
Butyl Benzyl phthalate (BBP)
Mono-Benzyl phthalate (mBzP)
Mono-n-Butyl phthalate (mBP)
Mono (3-carboxypropyl) phthalate (mCPP)
Mono-ethyl phthalate (MEtP)
Mono-2-ethylhexyl phthalate (MEHP)
Mono-(2-ethy-5-hydroxyhexyl) phthalate (MEHHP)
Mono-(2-ethy-5-oxohexyl) phthalate (MEOHP)
Mono-n-octyl phthalate (mOP)
Phthalic Acid
Quinolinic Acid
Volatile Organic Compounds
2-hydroxyethyl-mercapturic acid (HEMA)
Mandelic Acid
Phenylglyoxylic Acid
Mandelic Acid + Phenylglyoxylic Acid
Benzenes Exposure
t,t-Muconic Acid
3,4-Dimethylhippuric Acid
Toluene Exposure
Hippuric Acid
Benzoic Acid
Xylene Exposure
2-Methylhippuric Acid
3-Methylhippuric Acid
Each report includes a personalised supplementation plan generated directly from the organic acid findings of your individual results.
It is not a generic recommendation but dynamically calculated for each person based on the specific metabolic pattern identified across all measured domains.
A supplements schedule is generated using a proprietary weighted algorithm developed by the lab's clinical and scientific team.
The algorithm analyses the full pattern of organic acid results, not individual markers in isolation.
Then it assigns a weighted score to each finding based on its functional significance, its relationship to nutrient-dependent enzymatic pathways, and its interaction with other metabolic markers present in the same report.
The outcome of this calculation determines both the nutritional priority level (Adequate, Mild, Moderate, or High) and the suggested starting dose for each nutrient, amino acid, probiotic, or cofactor listed.
Important Disclaimer
The Nutrition Guide and supplementation suggestions in each report are generated only for the purposes of clinical decision-support and are not intended as standalone medical advice or a prescription.
The lab's proprietary algorithm used to generate supplement plan is based on established relationships between organic acid biomarkers and nutritional cofactor requirements.
However, it operates solely on biochemical data and cannot account for a person's complete medical history, current medications, existing diagnoses, organ function, pregnancy or breastfeeding status, or any other health condition that may influence the safety or appropriateness of the suggested nutrients and doses.
The final therapeutic decision including whether to implement, modify, or withhold any recommendation in this report rests entirely with the treating healthcare provider.
It is their responsibility to integrate these findings with the full clinical picture before making any therapeutic recommendation.
Our reports do not diagnose, treat, cure, or prevent any disease or medical condition.
High levels of organic pollutants and compounds forming the urinary metabolites are bad for health and signs of potential future problems. They are known to cause serious problems including fatigue, dizziness, seizures, liver and kidney disease, memory loss, personality changes.
An easy, low cost method of measuring your levels is by using a urine test at home. Simply order the test kit, collect the sample at home, ship it for free to our world class CLIA-certified labs, and find out your levels within days. Unlike a blood test, a urine sample makes it especially useful for those fearful of needles.
For detailed discussion on the human urine metabolites, please read this excellent review by The Metabolomics Innovation Center.
CDC has detailed explanation for many organic chemicals and their short and long term health impact here. More specifically, discussion about Benzene and Toluene toxicity, follow this summary by Vitale and Gutovitz.
A: Except New York and New Jersey our tests are available in all 48 states. State regulations in NY, NJ do not allow us to ship the tests to their residents.
A: The kit contains a urine collection strip, instructions on how to collect the samples, and a form requesting basic information including date and time of collection. The directions are straight forward and easy to follow. Your kit includes FREE return shipping (within US). We can ship to an address outside US but you will need to pay for return shipping.
A: You will receive the kit within 3-5 business days. After you ship the sample and it is received by our lab, you get the results within 10-12 business days (this test requires more time due to such a large number of markers). We also offer an option of shipping through USPS Priority Mail for faster delivery.
A: The report with your test results will be easy to understand and will have all the necessary details.
It will mark your levels on a healthy range and will specify what are the expected low and high ranges.
It will briefly discuss what your numbers mean and next steps you should take to maintain healthy levels.
A detailed explanation of markers flagged in your sample is also included.
For this test, the report also includes a supplement recommendation plan.
A: You can use HSA (or FSA/MSA/HRA) accounts to pay for the tests since these are prescription tests (for further confirmation, please check the IRS publication#969). However, please ensure you are not going outside your specified max and min deductible limits. We do not have the capability to process the insurance claim. Since insurance plans vary for individuals we can not guarantee your HSA payment will always be processed by your plan. We suggest talking to your insurance provider if you have any questions.
A: Measuring organic pollutants and metabolites levels in urine is an emerging field.
The variations in results are mainly from two sources: the way samples are collected and the variation from lab-to-lab.
To minimize the first variation, we provide detailed instructions on how to collect the sample.
To minimize the variation from labs, we have partnered with CLIA-certified labs that are regulated by the states, as well as Centers for Medicare and Medicaid Services (CMS). Many tests from these labs are FDA approved to ensure they meet the proper regulatory requirements. Additionally, the College of American Pathologists (CAP) requires inter-laboratory tests to ensure the ranges established by each lab do not drift or are not out of acceptable ranges. This is done by regularly testing reference samples between different labs. Finally, the labs test thousands of samples for different age groups and health conditions, and have well established reference data to compare your results against this large pool.
A: Unfortunately, no. As a lab test provider we can only test and report out data from your sample. We are not authorized to provide any medical recommendations. But we strongly encourage you to discuss the results with your doctor for next steps.
It is the first step to understand why you start to often feel tired, fatigued, and dizzy. This at home organic acids and environmental pollutants test kit can help understand if your energy levels and health concerns are related to any excessive household chemicals that you are unaware of.
Long term presence of organic acids and pollutants can manifest into weight loss, behavior change, and other serious issues. Stress, depression, headaches, abdomen pain are commonly observed when levels are high. The test is an easy first step in understanding how your body is handling these toxins and what life style changes might be required to maintain health.
If you are struggling to sleep, feeling tired, are in constant pain, have unusual behavior change this urine pollutants test kit is a great way to check the the root cause.
Checking your metabolite levels is first step in learning what you might be consuming that's resulting in high levels of certain unhealthy compounds. This test combines two popular test panels to offer a more competitive price.
Better health results in better quality of life, and a test from RxHomeTest.com not only offers insight into various health related symptoms, but it can also serve as a motivation to treat each of these symptoms and have a better quality of life!
No lab visits or doctor appointments.
Urine test (no blood needed).
World class CLIA-certified labs.
Includes a doctor's prescription.
Fast, secure, and confidential reports.
Free shipping.
Qualifies for payment using HSA/FSA.
Still wondering how do you test organic acids and environmental pollutants as well as urinary metabolites?
Each at home test kit from RxHomeTest.com includes a prescription and detailed review of the results by one of our physicians at no extra cost. And all the shipping is free.
RxHomeTest.com processes your sample at the same CLIA-certified labs that doctors use. So rest assured your tests are being processed in a world class lab.
RxHomeTest.com offers convenient, confidential, and reliable results at one of the lowest prices. And we also offer a wide range of health tests.
You can order at home urine test kit online, without requiring a doctor’s visit or prescription, thus saving time and money. You do not need to take any time off for lab visits which makes the test very affordable.
Our urine pollutants test is more convenient than a blood test or serum cortisol test as you don’t need to draw any blood using needles.
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